Make Sure You Invest In The Right Bicycle!

Not so long ago, nobody would have named a product "Brooklyn".  It was the declasse downmarket cousin of Manhattan.  And, in certain circles, one could be judged (as I was) for having grown up in it.  When I moved to the borough as an adult, I lived in a neighborhood where nobody would admit to being from Brooklyn.  Instead, they told people they lived in Park Slope.  I'll admit, I fell into that guise a few times.

Now, of course, "Brooklyn" is cool. At least, if you moved there from someplace else.  Brooklyn's cachet isn't found in  just any of the borough's neighborhoods:  The one in which I grew up is not the hipster haven that Williamsburg--at least, a section of it--has become, and isn't a maze of young women in $200 yoga pants pushing $1500 strollers along bar- and restaurant-lined avenues, as "The Slope" has become.  When marketers and entrepreneurs name their products or emporia after Brooklyn, they're not thinking about East New York or Brownsville--or even, for that matter, the parts of Williamsburg south of the eponymous bridge and east of Union Avenue, where Hasidim and Hispanics, respectively, live.

Lately, it seems that "bicycle" is starting to gain status, however slowly, in much the same way Brooklyn is.  For as long as I can remember, the only non-bicycle related product named for the two-wheeler has been playing cards.  And they were so named in the days when a bike cost about as much as the average worker made in a year.  

Of course, you aren't going to find breakfast cereals or cosmetics named for anything velocipedic. At least, not now. That could change, however, very soon.  Slowly but surely, our two-wheeled obsession is gaining status--in one industry, anyway.

Interestingly, that area is biotechnology.  Perhaps it's not surprising when you realize that at scientists have likened the motion of at least one kind of molecule to the way pedals rotate around a bottom bracket.  

So now there is a company called Bicycle Therapeutics.  Now pharmaceutical giant Merck (funny, how much that looks like the name of the greatest racer of all time) has announced that it acquired a biotech startup that was ready to announce an Initial Public Offering.  

The name of that company is Peloton Therapeutics.

Nicholas Janski of Barron's wondered whether would-be investors might mistake the biotech company--which actually is applying some of the recently-discovered knowledge about the "bicycle" molecules I've mentioned--for Peloton Interactive, the maker of at-home "spin" bikes.  He cited similar confusion last month, when investors piled money into Zoom Technologies, causing the price of its stock to more than double, after Zoom Video Communications, an entirely unrelated company, announced its IPO.

(Me, when I hear "Zoom," I think of handlebars, stems, seatposts and other bike parts, mainly for mountain bikes!) 

Hmm...I wonder whether Eddie bought stock in any of those companies.  Does he think "Brooklyn" is cool?

Real Pedal Power?

I have to admit that I know nothing about molecular chemistry.  It's one of those areas, like much of physics, that sounds interesting but for which I lack the background, and possibly the aptitude (My math skills are, depending on your point of view, comically or frightfully bad!) to understand.

So when I read this article, all I knew was that scientists somehow managed to synthesize molecules that operate like the pedals of a bicycle. It sounded really cool.

 From what I understand, these molecules can be activated by light to act as "switches", moving from one structural state to another as they move like the pedals around a bottom bracket.  However, they do not perform a full rotation, but move back and forth in arcs around the "axle."

In contrast, other kinds of molecules exhibit large-scale rotation around one bond, and need much more space than the "pedal" molecules need in order to make the "switch".

Why is this important?  Well, "switching" is necessary in order to create the molecular structures necessary in a number of applicatons, from pharmaceuticals to computers.  I would imagine that it is also vital to much "green" technology.  

I once built a wheel that looked like this.  I didn't ride it, though!

As I understand, these molecules change their structure in a way analagous to that of water it becomes ice or vapor.  When water is heated, its vapor needs more space because it expands.  On the other hand, when water cools down to 4 degrees C, it contracts but, unlike other liquids, expands when it freezes. You can see this when a river or lake ices over.) Just as liquid water acts differently from vapor or ice when you try to combine it with other things, whether and how molecules bond depends on their structural state.  So, the necessary molecular structures for a number of things, from pharmaceuticals to plastics, can be created only when the molecules can reach the right state.  And that can only happen when the would-be "switches" are allowed to switch.  

If water in a pipe freezes, it will expand the pipe until it bursts.  On the other hand, if molecules in other environments are so restricted, they just don't move and therefore don't make the necessary "switches." That is the reason why researchers and engineers have been limited in what they can create.

The "pedal" motion, as it turns out, is more compact than other kinds of molecular motion.  This means the atoms that are part of the molecule aren't displaced much, if at all--which,  in turn, means that the molecule doesn't (and doesn't have to) move as much.  This could allow scientists and engineers to create new kinds of structures.

Of course, we as cyclists always knew that the pedaling motion was very economical and efficient--and, when performed even by people of ordinary ability, graceful.  Is it any wonder, then, that so much of today's technology--including that of automobiles and aircraft--came directly or indirectly from bicycles.  Now it looks like even more sophisticated technology will soon owe its debt to our beloved two-wheeled vehicles--in this case, our method of propulsion!